Publications
Clinical Neurophysiology Journal - Editor's Choice
Professor Robert Chen
Editor-in-Chief,
Clinical Neurophysiology
The Editor’s Choice | October 2026
Each month, Robert Chen, Editor-in-Chief of Clinical Neurophysiology, selects an Editor's Choice article highlighting noteworthy research from the latest issue, along with additional Editor's Choice highlights.
Cortical changes in amyotrophic lateral sclerosis: comparing biomarkers of glymphatic flow and cortical excitability
Clinical Neurophysiology Volume 190
Nathan Pavey, Sicong Tu, Sheryl Foster, Nimeshan Geevasinga, Aicee Calma, Yukiko Tsuji, Matthew C. Kiernan, Steve Vucic, Parvathi Menon
The glymphatic system plays an important role in removal of toxic and metabolic waste from the brain, and its dysfunction have been implicated in neurodegenerative diseases such as Alzheimer’s disease and amyotrophic lateral sclerosis (ALS). Cortical hyperexcitability may play a role in the pathophysiology of ALS. In this volume of Clinical Neurophysiology, Pavey et al. measured glymphatic function using diffusion weighted MRI and cortical excitability using transcranial magnetic stimulation in 35 ALS patients and 25 age-matched controls. The authors found reduced glymphatic function and cortical hyperexcitability in ALS patients. Glymphatic function correlated with cortical silent period duration, a measure related to GABAB-mediated cortical inhibition. The findings raised the intriguing possibility that cortical hyperexcitability in ALS could be related to impaired glymphatic function.
Additional Editor's Choice Highlights | October 2026
Editor's Choice Archive
Explore previous Editor's Choice selections from Clinical Neurophysiology.
- Can muscle ultrasound assessments aid in the diagnosis of Myasthenia gravis? Findings from a single-center case-control study
2026 September Vol. 189 - Resting-state EEG for continuous prognostic monitoring and prediction of coma recovery after acute brain injury
2026 August Vol. 188 - Impaired kinesthesia and cerebral integration during tendon vibration in amyotrophic lateral sclerosis
2026 July Vol. 187 - A multicentre randomized double-blind placebo-controlled study of lacosamide, pregabalin, and tapentadol on spinal pain biomarkers
2026 June Vol. 186 - Morpho-functional correlates of gait impairment in early Parkinson’s disease patients: insights from a multimodal path modeling framework.
2026 April Vol. 184 - Is EEG useful in predicting neurotoxicity and outcomes related to chimeric antigen receptor (CAR) T-cell therapy?
2026 March Vol. 183 - "Fascicular twitch" on muscle ultrasonography in neuromuscular disorders: quantitative video-image analysis
2026 February Vol. 182 - Automated estimation of EEG maturity in preterm neonates and its association with long-term outcome
2026 January Vol. 181
- Timing-dependent synergies between noninvasive motor cortex and spinal cord stimulation in chronic cervical spinal cord injury
2025 December Vol. 180 - Intermuscular coherence from muscle pairs in the leg as a biomarker for amyotrophic lateral sclerosis
2025 November Vol. 179 - Cortical inhibitory and facilitatory alterations in the continuum of alpha-synucleinopathies
2025 October Vol. 178 - Activation site estimation using induced current simulation and motor evoked potential latency in transcranial magnetic stimulation
2025 September Vol. 177 - Cerebellar grey matter volume predicts cerebellar tDCS efficacy in individuals with Friedreich ataxia
2025 August Vol. 176 - Dynamic functional connectivity is modulated by the amount of p-Tau231 in blood in cognitively intact participants
2025 July Vol. 175 - The role of high-density EEG in diagnosis and prognosis of neurological diseases: A systematic review.
2025 June Vol. 174 - Neurorehabilitation in spinal cord injury: Increased cortical activity through tDCS and robotic gait training
2025 May Vol. 173 - Machine learning-driven Heckmatt grading in facioscapulohumeral muscular dystrophy: A novel pathway for musculoskeletal ultrasound analysis
2025 April Vol. 172 - Trigeminal reflex testing abnormalities as a predictive model for distinguishing classical and idiopathic trigeminal neuralgia
2025 March Vol. 171 - High-density theta oscillatory-modulated tDCS over the parietal cortex for targeted memory enhancement
2025 February Vol. 170 - Association of abnormal cortical inhibition and clinical outcomes in patients at clinical high risk for psychosis
2025 January Vol. 169
- EEG aperiodic dynamics from early through late childhood: Associations with ADHD, cognition, and development
2024 December Vol. 168 - Breakdown of TMS evoked EEG signal propagation within the default mode network in Alzheimer’s disease
2024 November Vol. 167 - Cortical activation in REM behavior disorder mimics voluntary movement. An electroencephalography study
2024 October Vol. 166 - Role of Intraoperative Electroencephalography in Predicting Postoperative Delirium in Patients Undergoing Cardiovascular Surgeries
2024 August Vol. 164 - Emotional facial expression and perioral motor functions of the human auditory cortex
2024 July Vol. 163 - Trait-dependent effects of theta burst stimulation after psychosocial stress: a sham-controlled study in healthy individuals
2024 June Vol. 162 - Whole-body fasciculation detection in amyotrophic lateral sclerosis using motor unit MRI.
2024 May Vol. 161 - Distinct MRI-based functional and structural connectivity for antidepressant response prediction in major depressive disorder.
2024 April Vol. 160 - Axonal excitability as an early biomarker of nerve involvement in hereditary transthyretin amyloidosis.
2024 March Vol. 159 - Abnormal motor cortical plasticity as a useful neurophysiological biomarker for Alzheimer’s disease pathology
2024 February Vol. 158 - Parkinsonian rest tremor can be distinguished from voluntary hand movements based on subthalamic and cortical activity
2024 January Vol. 157
- Artificial intelligence-based classification of motor unit action potentials in real-world needle EMG recordings
2023 December Vol. 156 - DICOM® integrated EEG data: A first clinical implementation of the new DICOM standard for neurophysiology data
2023 November Vol. 155 - Ultrafast review of ambulatory EEGs with deep learning
2023 October Vol. 154 - Frequency-dependent tuning of the human vestibular "sixth sense" by transcranial oscillatory currents
2023 September Vol. 153 - Clinical neurophysiological interrogation of motor slowing: A critical step towards tuning adaptive deep brain stimulation.
2023 August Vol. 152 - Deficient GABABergic and glutamatergic excitability in the motor cortex of patients with long-COVID and cognitive impairment.
2023 July Vol. 151 - Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee
2023 June Vol. 150 - Image analysis can reliably quantify median nerve echogenicity and texture changes in patients with carpal tunnel syndrome
2023 May Vol. 149 - Cortical reactivity to transcranial magnetic stimulation predicts risk of post-stroke delirium
2023 April Vol. 148 - Passive functional mapping of receptive language cortex during general anesthesia using electrocorticography
2023 March Vol. 147 - Quantitative EEG signatures of delirium and coma in mechanically ventilated ICU patients
2023 February Vol. 146 - Detailed magnetoelectric analysis of a nerve impulse propagation along the brachial plexus
2023 January Vol. 145
- MRI-guided focused-ultrasound thalamotomy in essential tremor: Immediate and delayed changes in cortico-muscular coherence and cortico-cortical out-strength
2022 December Vol. 144 - Automated EEG-based prediction of delayed cerebral ischemia after subarachnoid hemorrhage
2022 November Vol. 143 - Vagal nerve stimulation cycles alter EEG connectivity in drug-resistant epileptic patients: A study with graph theory metrics
2022 October Vol. 142 - Sub-scalp electroencephalography: A next-generation technique to study human neurophysiology
2022 September Vol. 141 - Transcranial magnetic stimulation of the brain: What is stimulated?—A consensus and critical position paper
2022 August Vol. 140 - Virtual implantation using conventional scalp EEG delineates seizure onset and predicts surgical outcome in children with epilepsy
2022 July Vol. 139 - Transcranial electrical stimulation elicits short and long latency responses in the tongue muscles
2022 June Vol. 138 - EEG spectral exponent as a synthetic index for the longitudinal assessment of stroke recovery
2022 May Vol. 137 - Review of techniques useful for the assessment of sensory small fiber neuropathies: Report from an IFCN expert group
2022 April Vol. 136 - Non-invasive transcranial ultrasound stimulation for neuromodulation
2022 March Vol. 135 - Minimum standards for inpatient long-term video-EEG monitoring: A clinical practice guideline of the international league against epilepsy and international federation of clinical neurophysiology
2022 February Vol. 134 - TMS-induced brain connectivity modulation in Genetic Generalized Epilepsy
2022 January Vol. 133
- Machine learning for predicting levetiracetam treatment response in temporal lobe epilepsy
2021 December Vol. 132, Issue 12 - Early nociceptive evoked potentials (NEPs) recorded from the scalp
2021 November Vol. 132, Issue 11 - The reliability of cerebellar brain inhibition
2021 October Vol. 132, Issue 10 - Highly consistent temporal lobe interictal spike networks revealed from foramen ovale electrodes
2021 September Vol. 132, Issue 9 - Subclinical epileptiform activity accelerates the progression of Alzheimer’s disease: A long-term EEG study
2021 August Vol. 132, Issue 8 - Altered interhemispheric signal propagation in schizophrenia and depression
2021 July Vol. 132, Issue 7 - Alpha power decrease in quantitative EEG detects development of cerebral infarction after subarachnoid hemorrhage early
2021 June Vol. 132, Issue 6 - Automated seizure detection using wearable devices: A clinical practice guideline of the International League Against Epilepsy and the International Federation of Clinical Neurophysiology
2021 May Vol. 132, Issue 5 - Chronic fatigue syndrome: Abnormally fast muscle fiber conduction in the membranes of motor units at low static force load
2021 April Vol. 132, Issue 4 - Training in the practice of noninvasive brain stimulation: Recommendations from an IFCN committee
2021 March Vol. 132, Issue 3 - Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology
2021 February Vol. 132, Issue 2 - Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guideline
2021 January Vol. 132, Issue 1
- Association of cortical spreading depression and seizures in patients with medically intractable epilepsy
2020 December Vol. 131, Issue 12 - Clinical and advanced neurophysiology in the prognostic and diagnostic evaluation of disorders of consciousness: review of an IFCN-endorsed expert group
2020 November Vol. 131, Issue 11 - Stratifying chronic stroke patients based on the influence of contralesional motor cortices: An inter-hemispheric inhibition study
2020 October Vol. 131, Issue 10 - Age-related decline of neuroplasticity to intermittent theta burst stimulation of the lateral prefrontal cortex and its relationship with late-life memory performance
2020 September Vol. 131, Issue 9 - Separating posterior-circulation stroke from vestibular neuritis with quantitative vestibular testing
2020 August Vol. 131, Issue 8 - Cortical network dysfunction revealed by magnetoencephalography in carriers of spinocerebellar ataxia 1 or 2 mutation
2020 July Vol. 131, Issue 7 - Latency of subthalamic nucleus deep brain stimulation-evoked cortical activity as a potential biomarker for postoperative motor side effects
2020 June Vol. 131, Issue 6 - Characterizing vocal tremor in progressive neurological diseases via automated acoustic analyses
2020 May Vol. 131, Issue 5 - Visualization of electrophysiological activity at the carpal tunnel area using magnetoneurography
2020 April Vol. 131, Issue 4 - An Automatic Detection Method for 40-Hz Auditory Steady State Response and its Application in Prognosis of Comatose Patients
2020 March Vol. 131, Issue 3 - Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014–2018)
2020 February Vol. 131, Issue 2 - Measurement of axonal excitability: Consensus guidelines
2020 January Vol. 131, Issue 1
- Seventy years of our journal,
An electroencephalographer recalls the history of the Federation on the 70th anniversary of its journal, Clinical Neurophysiology,
An electromyographer recalls the history of the Federation on the 70th anniversary of its journal, Clinical Neurophysiology,
2019 December Vol. 130, Issue 12 - Analysis of electrooculography signals for the detection of Myasthenia Gravis
2019 November Vol. 130, Issue 11 - Stability of a chronic implanted brain-computer interface in late-stage amyotrophic lateral sclerosis
2019 October Vol. 130, Issue 10 - Standards for quantification of EMG and neurography
2019 September Vol. 130, Issue 9 - Seizures from transcranial magnetic stimulation 2012–2016: Results of a survey of active laboratories and clinics
2019 August Vol. 130, Issue 8 - Brain networks and their relevance for stroke rehabilitation
2019 July Vol. 130, Issue 7 - Botulinum neurotoxin serotype D – A potential treatment alternative for BoNT/A and B non-responding patients
2019 June Vol. 130, Issue 6 - Clinical utility and prospective of TMS-EEG
2019 May Vol. 130, Issue 5 - Assessing blink reflex circuits by three different afferent routes in Parkinson’s disease
2019 April Vol. 130, Issue 4 - Cortical networks are disturbed in people with cirrhosis even in the absence of neuropsychometric impairment
2019 March Vol. 130, Issue 3 - Interictal spike connectivity in human epileptic neocortex
2019 February Vol. 130, Issue 2 - Recommendations of the International Society of Intraoperative Neurophysiology for intraoperative somatosensory evoked potentials
2019 January Vol. 130, Issue 1
- Indications for neuromuscular ultrasound: Expert opinion and review of the literature
2018 December Vol. 129, Issue 12 - Decreasing subthalamic deep brain stimulation frequency reverses cognitive interference during gait initiation in Parkinson’s disease
2018 November Vol. 129, Issue 11 - Fasciculation intensity and disease progression in amyotrophic lateral sclerosis
2018 October Vol. 129, Issue 10 - Multi-component intrinsic brain activities as a safe alternative to cortical stimulation for sensori-motor mapping in neurosurgery
2018 September Vol. 129, Issue 9 - Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres
2018 August Vol. 129, Issue 8 - Decrease of motor cortex excitability following exposure to a 20 Hz magnetic field as generated by a rotating permanent magnet
2018 July Vol. 129, Issue 7 - Phantom somatosensory evoked potentials following selective intraneural electrical stimulation in two amputees
2018 June Vol. 129, Issue 6 - Clinical utility of EEG in diagnosing and monitoring epilepsy in adults
2018 May Vol. 129, Issue 5 - Vestibulo-cochlear function in inflammatory neuropathies
2018 April Vol. 129, Issue 4 - Sleep patterns associated with the severity of impairment in a large cohort of patients with chronic disorders of consciousness
2018 March Vol. 129, Issue 3 - Somatosensory Evoked Potentials and Central Motor Conduction Times in children with dystonia and their correlation with outcomes from Deep Brain Stimulation of the Globus pallidus internus
2018 February Vol. 129, Issue 2 - Abnormal functional connectivity of high-frequency rhythms in drug-naïve schizophrenia
2018 January Vol. 129, Issue 1
- Ear-EEG detects ictal and interictal abnormalities in focal and generalized epilepsy – A comparison with scalp EEG monitoring
2017 December Vol. 128 Issue 12 - Long term correlation of subthalamic beta band activity with motor impairment in patients with Parkinson’s disease
2017 November Vol. 128 Issue 11 - The standardized EEG electrode array of the IFCN
2017 October Vol. 128 Issue 10 - Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines
2017 September Vol. 128 Issue 9 - Reduced electrode arrays for the automated detection of rhythmic and periodic patterns in the intensive care unit: Frequently tried, frequently failed?
2017 August Vol. 128 Issue 8 - A novel methodology for assessing laryngeal and vagus nerve integrity in patients under general anesthesia
2017 July Vol. 128 Issue 7 - The evolution of motor cortical dysfunction in amyotrophic lateral sclerosis
2017 June Vol. 128 Issue 6 - Parietomotor connectivity in the contralesional hemisphere after stroke: A paired-pulse TMS study
2017 May Vol. 128 Issue 5 - Early disturbances in multimodal evoked potentials as a prognostic factor for long-term disability in relapsing-remitting multiple sclerosis patients
2017 April Vol. 128 Issue 4 - Pain perception in patients with chronic disorders of consciousness: What can limbic system tell us?
2017 March Vol. 128 Issue 3 - TMS combined with EEG in genetic generalized epilepsy: A phase II diagnostic accuracy study
2017 February Vol. 128 Issue 2 - Haemodialysis alters peripheral nerve morphology in end-stage kidney disease
2017 January Vol. 128 Issue 1
- The significance of ultrasonographic carpal tunnel outlet measurements in the diagnosis of carpal tunnel syndrome
2016 December Vol. 127 Issue 12 - Motor cortical dysfunction develops in spinocerebellar ataxia type 3
2016 November Vol. 127 Issue 11 - Intraoperative spinal cord monitoring using low intensity transcranial stimulation to remove post-activation depression of the H-reflex
2016 October Vol. 127 Issue 10 - The relationship between seizures, interictal spikes and antiepileptic drugs
2016 September Vol. 127 Issue 9 - Disease-specific sparing of the anterior semicircular canals in bilateral vestibulopathy
2016 August Vol. 127 Issue 8 - Brain areas with epileptic high frequency oscillations are functionally isolated in MEG virtual electrode networks
2016 July Vol. 127 Issue 7 - Cortical correlates of susceptibility to upper limb freezing in Parkinson’s disease
2016 June Vol. 127 Issue 6 - Normal pressure hydrocephalus: Increase of utricular input in responders to spinal tap test
2016 May Vol. 127 Issue 5 - Ascending vestibular drive is asymmetrically distributed to the inferior oblique motoneuron pools in a subset of hemispheric stroke survivors
2016 April Vol. 127 Issue 4 - Language mapping using high gamma electrocorticography, fMRI, and TMS versus electrocortical stimulation
2016 March Vol. 127 Issue 3 - Short pauses in thalamic deep brain stimulation promote tremor and neuronal bursting
2016 February Vol. 127 Issue 2 - Yield of MRI, high-density electric source imaging (HD-ESI), SPECT and PET in epilepsy surgery candidates
2016 January Vol. 127 Issue 1