Clinical Neurophysiology Journal - Editor's Choice

Professor Robert Chen
Editor-in-Chief, Clinical Neurophysiology

The Editor’s Choice—

Breakdown of TMS evoked EEG signal propagation within the default mode network in Alzheimer’s disease

Clinical Neurophysiology Volume 167 (November 2024)

Michele Maiella, Lucia Mencarelli, Elias P. Casula, Ilaria Borghi, Martina Assogna, Francesco di Lorenzo, Sonia Bonnì, Valentina Pezzopane, Alessandro Martorana, Giacomo Koch

Alzheimer's disease (AD) is the most common form of dementia. In this volume of Clinical Neurophysiology, Maiella et al. used a multimodal approach with transcranial magnetic stimulation evoked EEG responses (TMS-EEG), resting state functional magnetic resonance imaging (rsfMRI) and diffusion tensor imaging (DTI) tractography to investigate brain connectivity in AD. The study specifically targeted the default mode network (DMN), identified based on fMRI studies, which includes the precuneus, anterior cingulate cortex and inferotemporal cortex. When targeting the precuneus, TMS-EEG showed markedly impaired signal propagation within the DMN in AD compared to controls, and the results correlate with findings from functional and structural MRI. The results not only highlight impaired connectivity within the DMN as a notable finding in AD, but the utility of TMS-EEG as a tool to assess brain connectivity with high temporal resolution in neurological and psychiatric disorders.

Editor Choice- Highlights (November 2024)

• Infant sleep spindle measures from EEG improve prediction of cerebral palsy
• Intra-epidermal electrically evoked potentials are sensitive to detect degenerative cervical myelopathy suggesting their spinothalamic propagation
• Seizure forecasting with ultra long-term EEG signals

Read editor’s choice collection of articles:

• Cortical activation in REM behavior disorder mimics voluntary movement. An electroencephalography study
  2024 October Vol. 166
• Role of Intraoperative Electroencephalography in Predicting Postoperative Delirium in Patients Undergoing Cardiovascular Surgeries
  2024 August Vol. 164
• Emotional facial expression and perioral motor functions of the human auditory cortex
  2024 July Vol. 163
• Trait-dependent effects of theta burst stimulation after psychosocial stress: a sham-controlled study in healthy individuals
  2024 June Vol. 162
• Whole-body fasciculation detection in amyotrophic lateral sclerosis using motor unit MRI.
  2024 May Vol. 161
• Distinct MRI-based functional and structural connectivity for antidepressant response prediction in major depressive disorder.
  2024 April Vol. 160
• Axonal excitability as an early biomarker of nerve involvement in hereditary transthyretin amyloidosis.
  2024 March Vol. 159
• Abnormal motor cortical plasticity as a useful neurophysiological biomarker for Alzheimer’s disease pathology
  2024 February Vol. 158
• Parkinsonian rest tremor can be distinguished from voluntary hand movements based on subthalamic and cortical activity
  2024 January Vol. 157
• Artificial intelligence-based classification of motor unit action potentials in real-world needle EMG recordings
  2023 December Vol. 156
• DICOM® integrated EEG data: A first clinical implementation of the new DICOM standard for neurophysiology data
  2023 November Vol. 155
• Ultrafast review of ambulatory EEGs with deep learning
  2023 October Vol. 154
• Frequency-dependent tuning of the human vestibular "sixth sense" by transcranial oscillatory currents
  2023 September Vol. 153
• Clinical neurophysiological interrogation of motor slowing: A critical step towards tuning adaptive deep brain stimulation.
  2023 August Vol. 152
• Deficient GABABergic and glutamatergic excitability in the motor cortex of patients with long-COVID and cognitive impairment.
  2023 July Vol. 151
• Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee
  2023 June Vol. 150
• Image analysis can reliably quantify median nerve echogenicity and texture changes in patients with carpal tunnel syndrome
  2023 May Vol. 149
• Cortical reactivity to transcranial magnetic stimulation predicts risk of post-stroke delirium
  2023 April Vol. 148
• Passive functional mapping of receptive language cortex during general anesthesia using electrocorticography
  2023 March Vol. 147
• Quantitative EEG signatures of delirium and coma in mechanically ventilated ICU patients
  2023 February Vol. 146
• Detailed magnetoelectric analysis of a nerve impulse propagation along the brachial plexus
  2023 January Vol. 145
• MRI-guided focused-ultrasound thalamotomy in essential tremor: Immediate and delayed changes in cortico-muscular coherence and cortico-cortical out-strength
  2022 December Vol. 144
• Automated EEG-based prediction of delayed cerebral ischemia after subarachnoid hemorrhage
  2022 November Vol. 143
• Vagal nerve stimulation cycles alter EEG connectivity in drug-resistant epileptic patients: A study with graph theory metrics
  2022 October Vol. 142
• Sub-scalp electroencephalography: A next-generation technique to study human neurophysiology
  2022 September Vol. 141
• Transcranial magnetic stimulation of the brain: What is stimulated?—A consensus and critical position paper
  2022 August Vol. 140
• Virtual implantation using conventional scalp EEG delineates seizure onset and predicts surgical outcome in children with epilepsy
  2022 July Vol. 139
• Transcranial electrical stimulation elicits short and long latency responses in the tongue muscles
  2022 June Vol. 138
• EEG spectral exponent as a synthetic index for the longitudinal assessment of stroke recovery
  2022 May Vol. 137
• Review of techniques useful for the assessment of sensory small fiber neuropathies: Report from an IFCN expert group
  2022 April Vol. 136
• Non-invasive transcranial ultrasound stimulation for neuromodulation
  2022 March Vol. 135
• Minimum standards for inpatient long-term video-EEG monitoring: A clinical practice guideline of the international league against epilepsy and international federation of clinical neurophysiology
  2022 February Vol. 134
• TMS-induced brain connectivity modulation in Genetic Generalized Epilepsy
  2022 January Vol. 133
• Machine learning for predicting levetiracetam treatment response in temporal lobe epilepsy
  2021 December Vol. 132, Issue 12
• Early nociceptive evoked potentials (NEPs) recorded from the scalp
  2021 November Vol. 132, Issue 11
• The reliability of cerebellar brain inhibition
  2021 October Vol. 132, Issue 10
• Highly consistent temporal lobe interictal spike networks revealed from foramen ovale electrodes
  2021 September Vol. 132, Issue 9
• Subclinical epileptiform activity accelerates the progression of Alzheimer’s disease: A long-term EEG study
  2021 August Vol. 132, Issue 8
• Altered interhemispheric signal propagation in schizophrenia and depression
  2021 July Vol. 132, Issue 7
• Alpha power decrease in quantitative EEG detects development of cerebral infarction after subarachnoid hemorrhage early
  2021 June Vol. 132, Issue 6
• Automated seizure detection using wearable devices: A clinical practice guideline of the International League Against Epilepsy and the International Federation of Clinical Neurophysiology
  2021 May Vol. 132, Issue 5
• Chronic fatigue syndrome: Abnormally fast muscle fiber conduction in the membranes of motor units at low static force load
  2021 April Vol. 132, Issue 4
• Training in the practice of noninvasive brain stimulation: Recommendations from an IFCN committee
  2021 March Vol. 132, Issue 3
• Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology
  2021 February Vol. 132, Issue 2
• Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guideline
  2021 January Vol. 132, Issue 1
• Association of cortical spreading depression and seizures in patients with medically intractable epilepsy
  2020 December Vol. 131, Issue 12
• Clinical and advanced neurophysiology in the prognostic and diagnostic evaluation of disorders of consciousness: review of an IFCN-endorsed expert group
  2020 November Vol. 131, Issue 11
• Stratifying chronic stroke patients based on the influence of contralesional motor cortices: An inter-hemispheric inhibition study
  2020 October Vol. 131, Issue 10
• Age-related decline of neuroplasticity to intermittent theta burst stimulation of the lateral prefrontal cortex and its relationship with late-life memory performance
  2020 September Vol. 131, Issue 9
• Separating posterior-circulation stroke from vestibular neuritis with quantitative vestibular testing
  2020 August Vol. 131, Issue 8
• Cortical network dysfunction revealed by magnetoencephalography in carriers of spinocerebellar ataxia 1 or 2 mutation
  2020 July Vol. 131, Issue 7
• Latency of subthalamic nucleus deep brain stimulation-evoked cortical activity as a potential biomarker for postoperative motor side effects
  2020 June Vol. 131, Issue 6
• Characterizing vocal tremor in progressive neurological diseases via automated acoustic analyses
  2020 May Vol. 131, Issue 5
• Visualization of electrophysiological activity at the carpal tunnel area using magnetoneurography
  2020 April Vol. 131, Issue 4
• An Automatic Detection Method for 40-Hz Auditory Steady State Response and its Application in Prognosis of Comatose Patients
  2020 March Vol. 131, Issue 3
• Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014–2018)
  2020 February Vol. 131, Issue 2
• Measurement of axonal excitability: Consensus guidelines
  2020 January Vol. 131, Issue 1
• Seventy years of our journal,
  An electroencephalographer recalls the history of the Federation on the 70th anniversary of its journal, Clinical Neurophysiology,
  An electromyographer recalls the history of the Federation on the 70th anniversary of its journal, Clinical Neurophysiology,
  2019 December Vol. 130, Issue 12
• Analysis of electrooculography signals for the detection of Myasthenia Gravis
  2019 November Vol. 130, Issue 11
• Stability of a chronic implanted brain-computer interface in late-stage amyotrophic lateral sclerosis
  2019 October Vol. 130, Issue 10
• Standards for quantification of EMG and neurography
  2019 September Vol. 130, Issue 9
• Seizures from transcranial magnetic stimulation 2012–2016: Results of a survey of active laboratories and clinics
  2019 August Vol. 130, Issue 8
• Brain networks and their relevance for stroke rehabilitation
  2019 July Vol. 130, Issue 7
• Botulinum neurotoxin serotype D – A potential treatment alternative for BoNT/A and B non-responding patients
  2019 June Vol. 130, Issue 6
• Clinical utility and prospective of TMS-EEG
  2019 May Vol. 130, Issue 5
• Assessing blink reflex circuits by three different afferent routes in Parkinson’s disease
  2019 April Vol. 130, Issue 4
• Cortical networks are disturbed in people with cirrhosis even in the absence of neuropsychometric impairment
  2019 March Vol. 130, Issue 3
• Interictal spike connectivity in human epileptic neocortex
  2019 February Vol. 130, Issue 2
• Recommendations of the International Society of Intraoperative Neurophysiology for intraoperative somatosensory evoked potentials
  2019 January Vol. 130, Issue 1
• Indications for neuromuscular ultrasound: Expert opinion and review of the literature
  2018 December Vol. 129, Issue 12
• Decreasing subthalamic deep brain stimulation frequency reverses cognitive interference during gait initiation in Parkinson’s disease
  2018 November Vol. 129, Issue 11
• Fasciculation intensity and disease progression in amyotrophic lateral sclerosis
  2018 October Vol. 129, Issue 10
• Multi-component intrinsic brain activities as a safe alternative to cortical stimulation for sensori-motor mapping in neurosurgery
  2018 September Vol. 129, Issue 9
• Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres
  2018 August Vol. 129, Issue 8
• Decrease of motor cortex excitability following exposure to a 20 Hz magnetic field as generated by a rotating permanent magnet
  2018 July Vol. 129, Issue 7
• Phantom somatosensory evoked potentials following selective intraneural electrical stimulation in two amputees
  2018 June Vol. 129, Issue 6
• Clinical utility of EEG in diagnosing and monitoring epilepsy in adults
  2018 May Vol. 129, Issue 5
• Vestibulo-cochlear function in inflammatory neuropathies
  2018 April Vol. 129, Issue 4
• Sleep patterns associated with the severity of impairment in a large cohort of patients with chronic disorders of consciousness
  2018 March Vol. 129, Issue 3
• Somatosensory Evoked Potentials and Central Motor Conduction Times in children with dystonia and their correlation with outcomes from Deep Brain Stimulation of the Globus pallidus internus
  2018 February Vol. 129, Issue 2
• Abnormal functional connectivity of high-frequency rhythms in drug-naïve schizophrenia
  2018 January Vol. 129, Issue 1
• Ear-EEG detects ictal and interictal abnormalities in focal and generalized epilepsy – A comparison with scalp EEG monitoring
  2017 December Vol. 128 Issue 12
• Long term correlation of subthalamic beta band activity with motor impairment in patients with Parkinson’s disease
  2017 November Vol. 128 Issue 11
• The standardized EEG electrode array of the IFCN
  2017 October Vol. 128 Issue 10
• Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines
  2017 September Vol. 128 Issue 9
• Reduced electrode arrays for the automated detection of rhythmic and periodic patterns in the intensive care unit: Frequently tried, frequently failed?
  2017 August Vol. 128 Issue 8
• A novel methodology for assessing laryngeal and vagus nerve integrity in patients under general anesthesia
  2017 July Vol. 128 Issue 7
• The evolution of motor cortical dysfunction in amyotrophic lateral sclerosis
  2017 June Vol. 128 Issue 6
• Parietomotor connectivity in the contralesional hemisphere after stroke: A paired-pulse TMS study
  2017 May Vol. 128 Issue 5
• Early disturbances in multimodal evoked potentials as a prognostic factor for long-term disability in relapsing-remitting multiple sclerosis patients
  2017 April Vol. 128 Issue 4
• Pain perception in patients with chronic disorders of consciousness: What can limbic system tell us?
  2017 March Vol. 128 Issue 3
• TMS combined with EEG in genetic generalized epilepsy: A phase II diagnostic accuracy study
  2017 February Vol. 128 Issue 2
• Haemodialysis alters peripheral nerve morphology in end-stage kidney disease
  2017 January Vol. 128 Issue 1
• The significance of ultrasonographic carpal tunnel outlet measurements in the diagnosis of carpal tunnel syndrome
  2016 December Vol. 127 Issue 12
• Motor cortical dysfunction develops in spinocerebellar ataxia type 3
  2016 November Vol. 127 Issue 11
• Intraoperative spinal cord monitoring using low intensity transcranial stimulation to remove post-activation depression of the H-reflex
  2016 October Vol. 127 Issue 10
• The relationship between seizures, interictal spikes and antiepileptic drugs
  2016 September Vol. 127 Issue 9
• Disease-specific sparing of the anterior semicircular canals in bilateral vestibulopathy
  2016 August Vol. 127 Issue 8
• Brain areas with epileptic high frequency oscillations are functionally isolated in MEG virtual electrode networks
  2016 July Vol. 127 Issue 7
• Cortical correlates of susceptibility to upper limb freezing in Parkinson’s disease
  2016 June Vol. 127 Issue 6
• Normal pressure hydrocephalus: Increase of utricular input in responders to spinal tap test
  2016 May Vol. 127 Issue 5
• Ascending vestibular drive is asymmetrically distributed to the inferior oblique motoneuron pools in a subset of hemispheric stroke survivors
  2016 April Vol. 127 Issue 4
• Language mapping using high gamma electrocorticography, fMRI, and TMS versus electrocortical stimulation
  2016 March Vol. 127 Issue 3
• Short pauses in thalamic deep brain stimulation promote tremor and neuronal bursting
  2016 February Vol. 127 Issue 2
• Yield of MRI, high-density electric source imaging (HD-ESI), SPECT and PET in epilepsy surgery candidates
  2016 January Vol. 127 Issue 1